You‐Hee Cho

This study shows that MucP, a protease in Pseudomonas aeruginosa, reduces RNA phage PP7 lysis by targeting its lysis protein's transmembrane helix, providing resistance against phage-induced cell lysis.

The paper identifies insertion-tolerant regions in RNA phages MS2 and PP7, enabling capsid engineering of PP7 with enhanced in vivo clearance.

This paper uses a cDNA-based functional selection strategy to identify RNA phage defense systems in Pseudomonas aeruginosa, uncovering new defense mechanisms and characterizing ZwsA as an RNA endonuclease.