NeuroscienceFrontiers in StrokePeer-reviewed
Adenosine A1R/A3R Agonist AST-004 Reduces Brain Infarction in Mouse and Rat Models of Acute Ischemic Stroke
Elizabeth S. Fisher, Yanan Chen, Mikaela M. Sifuentes…·James Donald Lechleiter
This study shows AST-004, an A1R/A3R agonist, reduces brain infarction in mouse and rat stroke models, with efficacy dependent on A3R signaling and astrocyte mitochondrial metabolism.