Adenosine A1R/A3R Agonist AST-004 Reduces Brain Infarction in Mouse and Rat Models of Acute Ischemic Stroke
Elizabeth S. Fisher, Yanan Chen, Mikaela M. Sifuentes, Jeremy J. Stubblefield, Damian Lozano, Deborah M. Holstein, JingMei Ren, Matthew S. Davenport, Nicholas DeRosa, Tsung-pei Chen, Gerard Nickel, Theodore E. Liston, James Donald Lechleiter
This study shows AST-004, an A1R/A3R agonist, reduces brain infarction in mouse and rat stroke models, with efficacy dependent on A3R signaling and astrocyte mitochondrial metabolism.
Frontiers in Stroke · Nov 22, 2022Peer-reviewedNeuroscience