This study identifies the lncRNA Dory as essential for female spatial memory and balance, with no effect in males, using CRISPR and RNA sequencing in mice.

bioRxiv · Jun 16, 2026 · PreprintNeuroscience

Long Read Sequencing reveals transgene concatemerization and backbone integration following AAV-driven electroporation of CRISPR RNP complexes in mouse zygotes

Muhammad Waqas Luqman, Piroon Jenjaroenpun, Jessica Spathos, Nikhil Shingte, Mitchell J Cummins, Pattaraporn Nimsamer, Lars Matthias Ittner, Thidathip Wongsurawat, Fabien Delerue

The paper uses long-read sequencing to analyze unintended on-target mutations in mouse zygotes edited with AAV-delivered CRISPR RNP complexes.

Frontiers in Genome Editing · Jun 4, 2025Peer-reviewedBioengineering

The neuroprotective effects of estrogen and estrogenic compounds in spinal cord injury

Artur Shvetcov, Marc Jan Ruitenberg, Fabien Delerue, Wendy Anne Gold, David Alexander Brown, Caitlin A. Finney

This review evaluates estrogen and estrogenic compounds' neuroprotective effects in spinal cord injury, finding they reduce inflammation and improve functional outcomes.

Neuroscience & Biobehavioral Reviews · Feb 1, 2023Peer-reviewedNeuroscience

Artificial intelligence-driven meta-analysis of brain gene expression identifies novel gene candidates and a role for mitochondria in Alzheimers Disease

Caitlin A. Finney, Fabien Delerue, Wendy Anne Gold, David Alexander Brown, Artur Shvetcov

This study uses AI-driven meta-analysis of brain gene expression data to identify novel gene candidates and highlights mitochondrial dysfunction in Alzheimer's disease.

Computational and Structural Biotechnology Journal · Dec 15, 2022Peer-reviewedGenetic & Genomic Medicine