Mitchell J Cummins

This study identifies the lncRNA Dory as essential for female spatial memory and balance, with no effect in males, using CRISPR and RNA sequencing in mice.

The paper links GWAS-associated haplotype blocks to lncRNAs and their mammalian orthologs, showing strong functional associations with complex traits.

The paper uses long-read sequencing to analyze unintended on-target mutations in mouse zygotes edited with AAV-delivered CRISPR RNP complexes.

The paper investigates aging effects on blood-CNS barriers in mice, finding no increase in paracellular permeability but changes in gene expression related to immune invasion and pericytes.