Saar I. Gill

The paper identifies suppressive atypical memory B cells in AML that are amplified by CAR T cell interactions and shows that targeting both B cells and AML blasts can overcome this suppression.

scDNA is a toolkit for analyzing single-cell DNA data to identify subclonal structures, mutation trajectories, and sample quality, with applications in cancer research.

The paper introduces a combined enzymatic and computational pipeline to identify off-target base-editing sites in human cells on a genome-wide scale.

The paper validates off-target effects of CRISPR/Cas9 in rhesus macaques using error-corrected sequencing, showing that in vitro and in silico methods have limited predictive accuracy.