Michael Bowman

SupeRJump identifies differentiation fate and discontinuous transitions in leukemia using a semi-supervised jump diffusion model applied to scRNA-seq data.

scDNA is a toolkit for analyzing single-cell DNA data to identify subclonal structures, mutation trajectories, and sample quality, with applications in cancer research.

This study identifies GGPP, a mevalonate pathway byproduct, as critical for chemoresistance in TP53mut AML through ROS regulation and mitochondria stress response, suggesting statin-based therapies could be effective.