Author

Aoife M. Roche

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

Frequent Co-Authors

Frederic D. BushmaniD· 2 shared Adeline L. VanderveriD· 1 shared Alexander G. McFarlandiD· 1 shared Amaliris GuerraiD· 1 shared Carlo Castruccio CastracaniiD· 1 shared Danuta Jadwiga Jarocha· 1 shared Davin Tafuri· 1 shared Elahe Kamali Ghahe· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Frederic D. BushmanORCID

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2 papers

Recent·Most cited

An integrated enzymatic and computational pipeline for quantifying off-target base-editing

Alexander G. McFarland, Soon‐Keat Ooi, Davin Tafuri, Elahe Kamali Ghahe, Natalie Cooper, Emma J. Cook, Shantan G. Reddy, Danuta Jadwiga Jarocha, Nils Wellhausen, Saar I. Gill, Aoife M. Roche, Joseph A. Fraietta, Frederic D. Bushman, Friederike Herbst

The paper introduces a combined enzymatic and computational pipeline to identify off-target base-editing sites in human cells on a genome-wide scale.

bioRxiv · Aug 26, 2025 · PreprintMolecular Biology

Effective Gene Therapy for Metachromatic Leukodystrophy Achieved with Minimal Lentiviral Genomic Integrations

Lucas Tricoli, Sunetra Sase, Julia Liao Hacker, Vi Pham, Maxwell Chappell, Laura Breda, Stephanie N. Hurwitz, Naoto Tanaka, Carlo Castruccio Castracani, Amaliris Guerra, Zhongqi Hou, Lars Schlotawa, Karthikeyan Radhakrishnan, Matthew Hogenauer, Aoife M. Roche, , Stefano Rivella

This paper develops a novel lentiviral vector for gene therapy of MLD that achieves high ARSA activity with minimal genomic integrations, improving safety and efficacy in preclinical models.

Molecular Therapy — Nucleic Acids · Jan 25, 2025Peer-reviewedMolecular Biology