Robert L. Bowman

SupeRJump: Determining normal and leukemic differentiation fate through semi-supervised jump diffusion modeling

SupeRJump identifies differentiation fate and discontinuous transitions in leukemia using a semi-supervised jump diffusion model applied to scRNA-seq data.

Prognostic and Therapeutic Implications of BRAF Mutations in Acute Myeloid Leukemia

This study identifies BRAF mutations in AML, showing poor outcomes and unique co-mutation patterns, suggesting potential targeted therapies.

Genotype-immunophenotype relationships in NPM1-mutant AML clonal evolution uncovered by single cell multiomic analysis

This study uses single-cell multiomic analysis to reveal genotype-immunophenotype relationships and clonal evolution in NPM1-mutant AML across disease stages.

Leukemia stem cell expansion cultures reveal clonal drivers of leukemogenesis and therapy response

This paper develops PLSTCs to expand AML LSCs and identifies clonal drivers of leukemogenesis and therapy response through genomic and single-cell analyses.

PTPN11 Mutation Clonal Hierarchy in Acute Myeloid Leukemia

This study identifies PTPN11 mutations as potential initiating events in AML when paired with NPM1 mutations, revealing their co-driver role and immune diversity in patient samples.

scDNA: Single Cell DNA analysis software toolkit for subclonality discovery and assessment.

scDNA is a toolkit for analyzing single-cell DNA data to identify subclonal structures, mutation trajectories, and sample quality, with applications in cancer research.

Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis

The paper examines rRNA transcription and abundance in normal and leukemic hematopoiesis, finding cell-type-specific variations and functional roles in myeloid differentiation.

Joint representation and visualization of derailed cell states with Decipher

Decipher is a deep generative model that integrates single-cell RNA-seq data to visualize and characterize transitions between normal and perturbed cell states across different diseases.

Chemoresistance of TP53 mutant AML requires the mevalonate byproduct, GGPP, for regulation of ROS and induction of a mitochondria stress response

This study identifies GGPP, a mevalonate pathway byproduct, as critical for chemoresistance in TP53mut AML through ROS regulation and mitochondria stress response, suggesting statin-based therapies could be effective.

Targetable Treatment Resistance in Thyroid Cancer with Clonal Hematopoiesis

This study identifies TET2-mutant clonal hematopoiesis in thyroid cancer microenvironments and shows that TGFβ signaling from these macrophages mediates resistance to BRAF/MEK inhibition, with TGFβ inhibition restoring sensitivity.

PURE-seq identifies Egr1 as a Potential Master Regulator in Murine Aging by Sequencing Long-Term Hematopoietic Stem Cells