Author

Friederike Herbst

University of PennsylvaniaORCID 0000-0002-2167-750XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:CITE-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Frederic D. BushmaniD· 2 shared Joseph A. FraiettaiD· 2 shared Aditi ChandraiD· 1 shared Alexander G. McFarlandiD· 1 shared Alexander J. DimitriiD· 1 shared Alexander T. DilsiD· 1 shared Amy E. BaxteriD· 1 shared Aoife M. Roche· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Frederic D. BushmanORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintAug 26, 2025

An integrated enzymatic and computational pipeline for quantifying off-target base-editing

Alexander G. McFarland, Soon‐Keat Ooi, Davin Tafuri…·Friederike Herbst

The paper introduces a combined enzymatic and computational pipeline to identify off-target base-editing sites in human cells on a genome-wide scale.

DOI 10.1101/2025.08.26.667396

humanDNA methylation

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ImmunologyScience AdvancesPeer-reviewedNov 13, 2024

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function

Alexander J. Dimitri, Amy E. Baxter, Gregory M. Chen…·Joseph A. Fraietta

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

42 citationstop 2%

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