Maria Pires Pacheco

EpiATLAS provides a comprehensive collection of human reference epigenomes to advance epigenomic research and understanding of cellular function and disease.

FASTERCC improves metabolic network analysis by accelerating flux consistency testing and reconstruction, reducing runtime by 20-fold for large networks.

The paper reconstructs metabolic networks across 58 human tissues and cell types using RNA-seq and epigenomic data, identifying core and cell-type-specific metabolic functions and their regulatory elements.

This study shows DJ-1 affects metabolism and immune response differently in Parkinson's disease and glioblastoma cells, with antioxidant treatment rescuing PD-related phenotypes.

This paper integrates external biomass reactions into metabolic models to improve prediction accuracy for gene essentiality and growth.