Lasse Sinkkonen

EpiATLAS provides a comprehensive collection of human reference epigenomes to advance epigenomic research and understanding of cellular function and disease.

This study identifies ZFHX4 as a key regulator of midbrain dopaminergic neuron differentiation by controlling cell cycle progression through the LIN28A-miR-9 axis.

The paper identifies Parkinson's disease-associated regulatory variants in human dopaminergic neurons and shows they modulate SCARB2 and BAG3 expression.

The paper reconstructs metabolic networks across 58 human tissues and cell types using RNA-seq and epigenomic data, identifying core and cell-type-specific metabolic functions and their regulatory elements.

The paper introduces BoNesis, a tool for inferring Boolean networks from transcriptome data to model cellular differentiation and reprogramming, demonstrating its application in hematopoiesis and adipocyte/osteoblast differentiation.

This study shows DJ-1 affects metabolism and immune response differently in Parkinson's disease and glioblastoma cells, with antioxidant treatment rescuing PD-related phenotypes.

This study shows that epileptogenesis disrupts the circadian clock and alters diurnal transcriptomic rhythms in the mouse hippocampus, with implications for human epilepsy.

The paper shows that Park7 deletion causes sex-specific transcriptome changes in male mouse midbrain astrocytes via the NRF2-CYP1B1 axis, affecting oxidative stress and EMT processes.

The paper quantifies and integrates miRNA gene expression in single-cell studies, revealing age- and disease-related miRNA regulation in immune cells.

The paper profiles chromatin accessibility in ventral midbrain single nuclei from two mouse strains, identifies cell types and transcription factors, and finds regulatory variation specific to cell types.

This study uses Nanopore sequencing to analyze mtDNA methylation in human blood samples, finding low-level methylation across the genome but noting challenges with Guppy calling affecting results.

This study examines age-related changes in the nigro-striatal circuit across three mouse strains, revealing strain-specific differences in dopaminergic neuron integrity and highlighting the importance of considering strain and age in Parkinson's disease research.

The paper identifies Pttg1 as a key regulator of gene expression variation in mouse ventral midbrain across aging, showing its role in transcriptome shifts and cell-type-specific changes.

The paper identifies Col4a6 as a genetic regulator of striatal dopamine levels and axonal branching in mice through QTL mapping and RNA-seq analysis.

The paper identifies AHR and GLIS1 as key regulators of mesenchymal multipotency using temporal epigenomic and transcriptomic data from mouse bone marrow stromal cells.