Author

Pauline Mencke

University of LuxembourgORCID 0000-0002-5564-0385Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:gene regulatory network inference· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Ibrahim BoussaadiD· 4 shared Rejko KrügeriD· 4 shared Jochen OhnmachtiD· 2 shared Lasse SinkkoneniD· 2 shared Thomas SauteriD· 2 shared Adrien J Ries· 1 shared Alessia SciortinoiD· 1 shared Alireza PouyaiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersNeuroscience

Ibrahim BoussaadORCID

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Author profile →

4 papers

Recent·Most cited

Loss of the Parkinson's disease-associated protein DJ-1 impacts dopamine metabolism in astrocytes

Annika Wagener, Naiyareen Fareeza Mayeen, Stephan A. Müller, Sarah K. Tschirner, Brigitte Nuscher, Pauline Mencke, Stefan F. Lichtenthaler, Ibrahim Boussaad, Rejko Krüger, Lena F. Burbulla

This study shows that DJ-1 mutations impair astrocytic dopamine metabolism, leading to disrupted detoxification and potential contribution to Parkinson's disease pathogenesis.

bioRxiv · Nov 2, 2025 · PreprintNeuroscience

DJ-1 mediates regulation of metabolism and immune response in Parkinsons disease astrocytes and Glioblastoma cells

Pauline Mencke, Jochen Ohnmacht, Félicia Jeannelle, Adrien J Ries, Mónica Miranda de la Maza, Mathilde M. Ullrich, François Massart, Patrycja Mulica, Katja Badanjak, Zoé Hanss, Arkadiusz Rybicki, Paul M. A. Antony, Sylvie Delcambre, Giuseppe Arena, Gérald Cruciani, , Ibrahim Boussaad

This study shows DJ-1 affects metabolism and immune response differently in Parkinson's disease and glioblastoma cells, with antioxidant treatment rescuing PD-related phenotypes.

bioRxiv · Oct 31, 2024 · PreprintNeuroscience

Park7 deletion leads to age- and sex-specific transcriptome changes involving NRF2-CYP1B1 axis in mouse midbrain astrocytes

Sergio Helgueta, Tony Heurtaux, Alessia Sciortino, Yujuan Gui, Jochen Ohnmacht, Pauline Mencke, Ibrahim Boussaad, Rashi Halder, Pierre Garcia, Rejko Krüger, Michel Guy André Mittelbronn, Manuel Buttini, Thomas Sauter, Lasse Sinkkonen

The paper shows that Park7 deletion causes sex-specific transcriptome changes in male mouse midbrain astrocytes via the NRF2-CYP1B1 axis, affecting oxidative stress and EMT processes.

bioRxiv · Feb 23, 2024 · PreprintMolecular Biology

GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton

Christina Wolf, Alireza Pouya, Sara Bitar, Annika Pfeiffer, Diones Bueno, Liliana Rojas-Charry, Sabine Arndt, David Gomez‐Zepeda, Stefan Tenzer, Federica Dal Bello, Caterina Vianello, Sandra Ritz, Jonas Schwirz, Kristina Dobrindt, Michael Peitz, , Axel Methner

This study identifies how GDAP1 loss of function disrupts actin signaling, leading to mitochondrial tubularity and metabolic changes in CMT4A.

Communications Biology · Jun 3, 2022Peer-reviewedNeuroscience