John P. Morrissey

Reconstruction of a catalogue of genome-scale metabolic models with enzymatic constraints using GECKO 2.0

The paper upgrades the GECKO method to create enzyme-constrained models for yeast and human, revealing common metabolic adaptations under stress.

Regulated use of alternative Transcription Start Sites controls the production of cytosolic or mitochondrial forms of branched-chain aminotransferase in Kluyveromyces marxianus

The paper investigates how alternative transcription start sites regulate the production of cytosolic and mitochondrial branched-chain aminotransferase proteoforms in Kluyveromyces marxianus, showing condition-specific regulation by transcription factors.

Transcriptional and translational profiling in yeast reveals the use of diverse genome decoding mechanisms to generate functionally distinct proteoforms

The paper identifies diverse genome decoding mechanisms in yeast that generate functionally distinct proteoforms and improves genome annotation.

Development of a Ribosome Profiling Protocol to Study Translation in the yeast Kluyveromyces marxianus

The paper develops a ribosome profiling protocol for Kluyveromyces marxianus and provides tools for data analysis and sharing.

Rational engineering of Kluyveromyces marxianus to create a chassis for the production of aromatic products

This paper rationally engineers Kluyveromyces marxianus to produce 2-phenylethanol from minimal medium, demonstrating a platform for aromatic product synthesis.

Stress-Induced Expression is Enriched for Evolutionarily Young Genes in Diverse Budding Yeasts

The paper identifies stress-induced genes in budding yeasts and finds they are enriched for young, non-essential genes that evolve rapidly.