Patrick B. F. O’Connor

The paper shows that reduced electron flux through complex IV leads to cytochrome c accumulation via increased stability and membrane retention, without increasing apoptosis sensitivity.

This study examines early transcriptional and translational changes in human T cells within four hours of activation, revealing dynamic gene expression and translation initiation patterns.

The paper identifies diverse genome decoding mechanisms in yeast that generate functionally distinct proteoforms and improves genome annotation.

The paper identifies a novel protein, POLGARF, encoded by an overlapping reading frame in POLG mRNA, showing efficient CUG initiation and evolutionary origins via MIR transposition.