Audrey M. Michel

This study examines early transcriptional and translational changes in human T cells within four hours of activation, revealing dynamic gene expression and translation initiation patterns.

This study identifies an ISR-independent role of GCN2 in preventing excessive ribosome biogenesis and mRNA translation, with implications for cancer therapy.

This study uses a small molecule inhibitor to rapidly and synchronously induce senescence-like features in human cells, enabling analysis of its core regulatory program without paracrine effects.

The paper identifies diverse genome decoding mechanisms in yeast that generate functionally distinct proteoforms and improves genome annotation.

The paper identifies a novel protein, POLGARF, encoded by an overlapping reading frame in POLG mRNA, showing efficient CUG initiation and evolutionary origins via MIR transposition.

This study shows mutant huntingtin (mHtt) stalls ribosomes and suppresses protein synthesis independently of FMRP, using ribosome profiling in HD cells and mouse models.

The paper develops a computational model to explain how a single upstream open reading frame (uORF) can upregulate downstream ORF translation during the Integrated Stress Response.