Moritz N. Helmstaedter

The paper analyzes astrocyte-synapse interactions in mouse somatosensory cortex using connectomic data, finding specific astrocytic coverage of certain synapse types and its potential role in synaptic stability.

The paper reports the connectomic reconstruction of a cortical column in mouse barrel cortex using 3D electron microscopy and AI-based image processing, revealing structural and functional insights into neuronal circuits.

RoboEM automates 3D flight tracing for synaptic-resolution connectomics, reducing computational annotation costs for cortical connectomes by about 400-fold compared to manual error correction.

The paper identifies a specialized disinhibitory network in cortical layer 4 driven by thalamic input, revealing subtype-specific connectivity patterns.

The paper introduces en-bloc staining and embedding protocols for high-contrast whole-brain samples to enable connectomic analyses at the mammalian level.

The paper examines the synaptic innervation patterns of apical tufts of cortical pyramidal cells in mice, revealing cell-type specific inhibitory input distributions.

The paper reports a dense connectomic reconstruction of mouse barrel cortex layer 4, revealing synaptic specificity and plasticity patterns in neuronal circuits.

FluoEM identifies multi-color fluorescent axons in 3D EM data without fiducial marks by matching neurite reconstructions from light microscopy.

SynEM automatically detects excitatory synapses in 3D electron microscopy images with high precision and recall, enabling large-scale connectomic analysis without manual annotation.