Yunfeng Hua

This study examines how altered medial olivocochlear (MOC) activity affects synaptic structure and function in the auditory brainstem using mouse models.

This study investigates the role of RTN4RL2 in cochlear synapse formation and function, finding that its deletion leads to synaptic abnormalities and hearing impairment in mice.

This paper develops a volumetric denoising approach to improve VEM acquisition speed and downstream analysis by optimizing resolution and noise handling.

This study shows that variations in Ca2+ channel activation in inner hair cells affect spiral ganglion neuron firing rates and sound threshold, with implications for noise-induced hearing loss in patients with the CaV1.3A749G mutation.

The paper investigates neuromodulation of the endbulb of Held synapse in the cochlear nucleus, finding that norepinephrine increases miniature excitatory postsynaptic currents while serotonin and evoked transmission are unaffected.

The paper introduces mito-SegEM, a method for efficiently mapping mitochondria in electron microscopy volumes using webKnossos, achieving accurate and efficient reconstruction across tissues.

This study shows noise-induced synaptopathy disproportionately affects long and short sensory hair cells in the mammalian cochlea, with distinct spatial patterns of ribbon synapse loss.

The paper identifies a specialized disinhibitory network in cortical layer 4 driven by thalamic input, revealing subtype-specific connectivity patterns.

The paper reconstructs neural circuitry in the mouse cochlea using electron microscopy, showing differences in efferent innervation of spiral ganglion neurons based on their synaptic connectivity with inner hair cells.