Mandy M. S. Lam

Postmitotic accumulation of histone variant H3.3 in new cortical neurons establishes neuronal chromatin, transcriptome, and identity

This study shows that de novo accumulation of H3.3 in postmitotic neurons is essential for establishing neuronal chromatin, transcriptome, and identity, distinct from its role in long-term histone maintenance.

Chromatin remodeler Arid1a regulates subplate neuron identity and wiring of cortical connectivity

This study shows that Arid1a is essential for subplate neuron function and cortical connectivity, with its loss causing axon miswiring and corpus callosum agenesis.

Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia

The paper introduces a machine learning method to detect somatic L1 insertions in human brain tissue, revealing their widespread distribution in neurons and glia and potential role in neuropsychiatric diseases.