Kenneth Y. Kwan

This study uses single-nucleus RNA sequencing to show psilocybin and ketamine induce cell type-specific and time-dependent gene expression changes in mouse medial frontal cortex neurons.

This study shows that Dscam overexpression in Down syndrome mouse models causes excessive GABAergic inhibition of neocortical pyramidal neurons.

DeepMosaic detects mosaic single nucleotide variants without control samples using deep convolutional neural networks, achieving high accuracy and uncovering many variants missed by existing methods.

This study shows that de novo accumulation of H3.3 in postmitotic neurons is essential for establishing neuronal chromatin, transcriptome, and identity, distinct from its role in long-term histone maintenance.

This study shows that Arid1a is essential for subplate neuron function and cortical connectivity, with its loss causing axon miswiring and corpus callosum agenesis.

The paper introduces a machine learning method to detect somatic L1 insertions in human brain tissue, revealing their widespread distribution in neurons and glia and potential role in neuropsychiatric diseases.