Jake Gockley

The paper identifies cross-domain drivers of Alzheimer's disease risk by integrating network analysis across biological domains.

The paper identifies two covalent inhibitors that disrupt the interaction between SYK's tandem SH2 domains and FCER1G phospho-ITAM, potentially beneficial for Alzheimer's disease therapy.

This paper identifies 8 genes across 6 genomic loci associated with Alzheimer's disease risk using transcriptome-wide association study and validates them with summary Mendelian randomization.

The paper identifies human-specific substitutions affecting enhancer activity in neurodevelopmental regions by testing their impact in human neural stem cells.

The paper disrupts enhancers and genes in human neural stem cells to study their effects on proliferation and identifies regulatory elements linked to neurodevelopmental disorders.