Benjamin A. Logsdon

Transcriptomically unique endolysosomal and homeostatic microglia populations in Alzheimer's disease and aged human brain

The paper identifies transcriptomically distinct microglia populations in Alzheimer's disease and aged human brains using single-nucleus RNA-seq and trajectory inference.

Manifestations of genetic risk for Alzheimer's Disease in the blood: a cross-sectional multi-omic analysis in healthy adults aged 18-90+

This study identifies blood-based biomarkers associated with Alzheimer's disease genetic risk variants in a large cohort of healthy adults, showing effects from early adulthood and sex-specific patterns.

Multi-Tissue Neocortical Transcriptome-Wide Associations Study Implicates 8 Genes Across 6 Genomic Loci in Alzheimer's Disease

This paper identifies 8 genes across 6 genomic loci associated with Alzheimer's disease risk using transcriptome-wide association study and validates them with summary Mendelian randomization.

Molecular estimation of neurodegeneration pseudotime in older brains

The paper estimates molecular pseudotime for Alzheimer's disease progression using RNA-Seq data from human brain samples, showing strong concordance with pathological markers and cognitive diagnosis.

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease

The paper introduces a NanoString nCounter Mouse AD panel to assess LOAD mouse models by correlating gene expression with human AD modules, showing strong correlation with RNA-Seq data.

Transcriptomic Stratification of Late-Onset Alzheimer’s Cases Reveals Novel Genetic Modifiers of Disease Pathology

This study identifies novel genetic modifiers of late-onset Alzheimer's disease by stratifying patients into molecular subtypes using transcriptomic data and whole genome sequencing.

Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia

The paper identifies brain microRNAs linked to late-life depressive symptoms and shows their association with cognitive decline and dementia risk.

Identifying and ranking potential driver genes of Alzheimer's Disease using multi-view evidence aggregation

The paper develops a multi-view evidence aggregation method to identify and rank potential driver genes of Alzheimer's Disease using RNA-Seq data and GWAS summary statistics.

Large-scale proteomic analysis of human prefrontal cortex identifies proteins associated with cognitive trajectory in advanced age

The paper identifies 579 proteins associated with cognitive trajectory in aging using proteomic analysis of human prefrontal cortex, highlighting mitochondrial and synaptic processes linked to cognitive stability.

Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological approach

Coexpression meta-analysis of 2114 human brain RNA-seq samples across the AMP-AD consortium identifies five consensus Alzheimer's disease transcriptional clusters, including two sex-heterogeneous clusters and a previously unreported proteostasis cluster.