Shuofeng Yuan

MetaSAG provides a tool for multi-level analysis of microbial single-amplified genomes, improving taxonomic classification and enabling functional and evolutionary insights.

This paper identifies 4-C-3 as an antitumor metabolite derived from cholesterol by gut microbiota, showing its efficacy in CRC models through dual inhibition of EGFR and KRAS.

This study identifies critical human host factors involved in SARS-CoV-2 multicycle replication through a genome-scale siRNA screen and validates potential antiviral targets.

This study shows SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids, upregulating interferon signaling linked to cytokine release syndrome.

The paper investigates how SARS-CoV-2 infection alters host cell metabolism and shows that ACE2 expression affects viral replication and infection outcomes.