Linda A. Barlow

This study shows that tyrosine kinase inhibitors cause taste dysfunction by altering the fate of taste cell subtypes through KIT inhibition.

The paper shows that high Sox2 expression in lingual progenitors predicts their ability to generate taste receptor cells and lingual epithelium in vitro.

The paper shows taste bud cell renewal begins at birth and SHH signaling shifts from repressing to promoting taste cell differentiation.

This study shows that SOX2, regulated by Hedgehog signaling, is essential for maintaining adult lingual epithelium homeostasis, including taste bud differentiation and epithelial cell balance.