Lauren A. Shechtman

This study identifies RasGRP1 as a regulator of tuft cell differentiation in the intestine, showing it restricts progenitor proliferation and enhances IL-13-driven responses.

The paper uses single-cell proteomics and metabolomics to study how Ras pathway mutations affect hematopoiesis, finding distinct impacts on HSC compartments and metabolism.

The paper shows that high Sox2 expression in lingual progenitors predicts their ability to generate taste receptor cells and lingual epithelium in vitro.

The paper shows taste bud cell renewal begins at birth and SHH signaling shifts from repressing to promoting taste cell differentiation.