Sascha H. C. Duttke

The paper identifies that unstable transcripts are rare in plants and often originate from promoters, challenging the use of genome annotations to infer enhancers.

The paper demonstrates that AVITI and Illumina sequencing technologies equally capture sRNA and csRNA libraries from human, cattle, and bison, revealing inaccuracies in genome annotations and highlighting the need for small RNA sequencing in livestock.

The paper shows that a single DPE core promoter motif mutation in Drosophila affects cardiac function by disrupting Tinman's regulatory network.

The paper profiles the active cistrome in peripheral leukocytes of critically ill COVID-19 patients to identify severity-associated cis-regulatory elements and their regulatory programs.

The paper investigates how drug exposure alters gene regulatory networks in the brain using multi-omics approaches, identifying enhancer repression and transcription factor involvement in addiction-related behaviors.

The paper revises transcription start site annotations in Chinese hamster genes using experimental data to improve gene engineering and glycosylation in CHO cells.

The paper identifies non-redundant DNA binding activities of AP-1 family members in macrophages using ChIP-sequencing and machine learning, showing motif ensembles drive factor-specific binding.