Author

John D. McPherson

Ontario Institute for Cancer ResearchORCID 0000-0001-8049-9347Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

John D. McPherson1 paper

Biology Disciplines

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Genomics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:long-read sequencing· 1 Organism:rat· 1

Frequent Co-Authors

Ada WongiD· 1 shared Aileen LuiD· 1 shared Alejandra V. PatinoiD· 1 shared Alexander D. BorowskyiD· 1 shared Allan B. Okey· 1 shared Chen-Shan ChiniD· 1 shared Cindy Q. Yao· 1 shared Elizabeth Hutton· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperGenomics

Ada WongORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 2, 2025

Adaptive selection of p53 mutation metaplastic phenotypes in estrogen-independent progression of ER+ tumors: A mechanism for acquired resistance to hormonal therapy.

Hyeongsun Moon, Hidetoshi Mori, Jane Chen…·Alexander D. Borowsky

This study shows that ER+ breast cancers can develop resistance to hormonal therapy through clonal selection of metaplastic p53-mutated basal cells in Stat1-/- mice.

DOI 10.1101/2025.02.02.636128

mousebulk RNA-seq

GenomicsArchives of ToxicologyPeer-reviewedSep 11, 2019

Identifying TCDD-resistance genes via murine and rat comparative genomics and transcriptomics

Stephenie D. Prokopec, Aileen Lu, Sandy Che-Eun S. Lee…·Paul Christopher Boutros

The paper identifies genes associated with TCDD-response phenotypes by comparing genomic and transcriptomic data from transgenic mice and rats.

7 citations

GenomicsGenome ResearchPeer-reviewedAug 1, 2018

Complex rearrangements and oncogene amplifications revealed by long-read DNA and RNA sequencing of a breast cancer cell line

Maria Nattestad, Sara Goodwin, Karen Ng…·Michael C. Schatz

The paper uses long-read sequencing to analyze structural variations in the SK-BR-3 breast cancer cell line, revealing complex rearrangements and novel gene fusions.

199 citations

humanwhole-genome sequencing