Cancer BiologybioRxivPreprint
Adaptive selection of p53 mutation metaplastic phenotypes in estrogen-independent progression of ER+ tumors: A mechanism for acquired resistance to hormonal therapy.
Hyeongsun Moon, Hidetoshi Mori, Jane Chen…·Alexander D. Borowsky
This study shows that ER+ breast cancers can develop resistance to hormonal therapy through clonal selection of metaplastic p53-mutated basal cells in Stat1-/- mice.
DOI 10.1101/2025.02.02.636128