Author

Jane Chen

University of California, IrvinePrimary ORCID profile (0000-0002-3986-8785 · 7 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Jane CheniD7 papers · Howard Hughes Medical Institute

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Alejandra V. PatinoiD· 1 shared Alexander D. BorowskyiD· 1 shared Angela G. FleischmaniD· 1 shared Brianna HooveriD· 1 shared Eli M. SoyferiD· 1 shared Eshika Arora· 1 shared Helen Q. Huang· 1 shared Hew Yeng LaiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Alejandra V. PatinoORCID

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2 papers

Recent·Most cited

Impaired IL-10 Receptor Signaling Leads to Inflammation Induced Exhaustion in Hematopoietic Stem Cells

William Lucas P Wadley, Helen Q. Huang, Hew Yeng Lai, Jianhong C Heidmann, Jane Chen, Eli M. Soyfer, Kalei Guillermo, Eshika Arora, Lauren Chen, Brianna Hoover, Angela G. Fleischman

This study shows that IL-10 receptor signaling prevents inflammation-induced hematopoietic stem cell exhaustion, and its blockade accelerates aging and promotes clonal expansion of Jak2V617F mutant HSCs.

bioRxiv · Sep 30, 2025 · PreprintCell Biology

Adaptive selection of p53 mutation metaplastic phenotypes in estrogen-independent progression of ER+ tumors: A mechanism for acquired resistance to hormonal therapy.

Hyeongsun Moon, Hidetoshi Mori, Jane Chen, Alejandra V. Patino, Zsófia Pénzváltó, Kavya Ramamurthy, Jaeyong Choi, John D. McPherson, Joshua C. Snyder, Robert D. Cardiff, Alexander D. Borowsky

This study shows that ER+ breast cancers can develop resistance to hormonal therapy through clonal selection of metaplastic p53-mutated basal cells in Stat1-/- mice.

bioRxiv · Feb 2, 2025 · PreprintCancer Biology