Alexander D. Borowsky

This study shows that the p95 isoform of HER2 promotes metastasis by biasing MRTFA-dependent signaling through specific tyrosine phosphorylation.

This study shows that cancer progression is nonlinear, with a critical occult transition leading to lethal tumors before detection, challenging the linear model of cancer growth.

This study shows that ER+ breast cancers can develop resistance to hormonal therapy through clonal selection of metaplastic p53-mutated basal cells in Stat1-/- mice.

This study identifies how changes in epithelial proportions and transcriptional states influenced by pregnancy and BMI affect hormone signaling and breast cancer risk in premenopausal women.

The paper creates a breast pre-cancer atlas by analyzing multiple micro-dissected regions from DCIS cases, revealing molecular and micro-environmental diversity and immune states associated with progression risk.

This paper develops a method to improve mutational profiling of pre-malignant lesions using degraded FFPE DNA, achieving better coverage and variant calling accuracy.