Sachin Patel

This study identifies a novel amygdala-dopamine circuit activated by adolescent stress that drives punishment-resistant reward-seeking behavior in mice.

This study shows that cannabinoid administration alters central amygdala somatostatin neuron activity and network dynamics, affecting threat-related behavior representation.

This study examines sex-specific synaptic changes in interneurons of the prelimbic cortex following alcohol withdrawal in mice.

This study shows that 2-AG levels inversely correlate with fear generalization in both mice and humans, suggesting a role in fear discrimination.

This study shows that deleting DAGLα in cerebellar Purkinje cells in mice leads to reduced social preference and increased anxiety.

The paper investigates the synaptic organization-function relationships of distinct amygdala interneuron classes during associative learning, revealing their unique roles in feedback and feedforward inhibition.

This study shows that enhancing 2-AG signaling reduces mechanical hypersensitivity during alcohol withdrawal in mice, suggesting it as a potential therapeutic target for AUD and comorbid pain.

This study shows that inhibiting diacylglycerol lipase reduces alcohol consumption in preclinical models and prevents ethanol-induced suppression of GABAergic transmission without causing anxiety or depression.