Talia N. Lerner

Coordinated spatial organization of basal ganglia structures revealed by dopamine subtype projectome mapping

The paper maps dopamine subtype projections in the basal ganglia to reveal spatially distinct domains and their correlation with striatal neuron subclasses and cortical inputs.

Dopamine dips during unrewarded actions promote punishment-resistant reward seeking

The paper shows that dopamine dips during unrewarded actions increase punishment-resistant reward seeking in female mice, with optogenetic mimicry accelerating this behavior in both sexes.

Adolescent stress recruits a latent amygdala-dopamine circuit to drive punishment-resistant reward-seeking

This study identifies a novel amygdala-dopamine circuit activated by adolescent stress that drives punishment-resistant reward-seeking behavior in mice.

Thalamus orchestrates local acetylcholine-dependent dopamine release in the learning striatum

The paper shows that thalamic input drives acetylcholine-dependent dopamine release in the dorsomedial striatum during learning, but not in the dorsolateral striatum.

Region-specific Nucleus Accumbens Dopamine Signals Encode Distinct Aspects of Avoidance Learning

This study investigates how dopamine signals in different nucleus accumbens subregions contribute to avoidance learning by analyzing their responses to aversive stimuli and learning progress.

Overexpression of alpha synuclein in Midbrain Dopamine Neurons Reduces Dopamine Release Without Cell Loss and Drives Mild Motor Deficits in Mice

Chronically elevated corticosterone impairsdopaminergic transmission in the dorsomedialstriatum by sex-divergent mechanisms

This study shows chronic corticosterone impairs reward-seeking in both sexes by sex-specific effects on dopamine content and transporter function in the dorsomedial striatum.

Striatonigrostriatal Circuit Architecture for Disinhibition of Dopamine Signaling

The paper investigates closed and open-loop striato-nigro-striatal circuits in the basal ganglia, finding evidence for functional synapses in open loops but questioning their role in crosstalk between striatal subregions.

Dopamine Signaling in the Dorsomedial Striatum Promotes Compulsive Behavior

This study shows that dopamine signaling in the dorsomedial striatum controls the development of compulsive reward-seeking behavior.

GuPPy, a Python toolbox for the analysis of fiber photometry data

GuPPy is a Python tool for analyzing fiber photometry data, offering a user-friendly interface and export capabilities for scientific figures.

Parvalbumin+ and Npas1+ Pallidal Neurons Have Distinct Circuit Topology and Function

This study identifies distinct roles of PV+ and Npas1+ neurons in the GPe for locomotion and shows differences in their synaptic inputs from the STN in Parkinson's disease.