Jacob A. Nadel

The paper shows that dopamine dips during unrewarded actions increase punishment-resistant reward seeking in female mice, with optogenetic mimicry accelerating this behavior in both sexes.

This study identifies a novel amygdala-dopamine circuit activated by adolescent stress that drives punishment-resistant reward-seeking behavior in mice.

This study shows that a ketone ester-enriched diet improves motor function and dopamine release in MitoPark mice with Parkinson's disease-like symptoms.

This study investigates how dopamine release in different striatal regions affects behavioral flexibility using optogenetics in mice.

This study shows that selectively increasing dopamine in the dorsal striatum impairs behaviors linked to negative and cognitive symptoms of psychosis, challenging the idea that excess dopamine is not involved in these symptoms.

This study uses optogenetics to investigate how striatal patches influence habit formation and dopamine signaling in mice.

This study shows that striatal patches are critical for maintaining habitual behaviors and behavioral stability, as their lesioning disrupts habitual responding and increases behavioral variability.