Hil G. E. Meijer

This study investigates how weak electric fields from deep brain stimulation (DBS) can modulate cortical neuron spike timing through computational models.

This study develops a biophysical model of the glutamate-glutamine cycle during ischemia, showing that synaptic failure is due to EAAT dysfunction and sodium gradient collapse, not glutamate release or glutamine synthetase.

The paper maps chondrogenic cell-fate trajectories in hiPSCs using scRNA-seq and scATAC-seq, identifying NFIA and NFIB as key regulators driving chondrogenic commitment.

DANSE models time-series multi-omics data to identify key transcription factors driving biological processes, using iPSC differentiation datasets as examples.

The paper uses fluorescent glutamate sensors to show that plume-like glutamate release events increase under metabolic stress, contributing to glutamate accumulation and excitotoxicity.

This paper develops a neural mass model to simulate EEG changes during cerebral ischemia, showing synaptic arrest precedes cell swelling and demonstrating the role of thalamocortical projections in EEG patterns.

This paper investigates how heterogeneity in the external pallidum (GPe) affects its dynamic regimes and response to oscillatory input, proposing hypotheses about dopamine depletion's effects on neural oscillations.