David G. Míguez

The paper identifies a signaling network motif where dimerization-linked nucleocytoplasmic shuttling couples protein expression levels with intracellular localization, modulating signaling cascade activity.

The paper shows the V-ATPase/ATG16L1 axis is essential for de novo lumen formation during epithelial tube morphogenesis.

This study identifies a core network structure that explains hormetic dose-response curves in drug development and applies it to rapamycin treatment.

The paper quantifies retinal neurogenesis dynamics, showing exponential growth and neuronal yield are regulated by Hedgehog signaling balancing differentiation and cell cycle duration.

This study shows that cell proliferation and Notch signaling work together to create epithelial folds in Drosophila leg development through mechanical forces and cell shape changes.

The paper studies how movement of the Hh morphogen source affects signaling dynamics in Drosophila organs, showing spatial and temporal differences in Ptc and CiA distribution.

OSCAR quantifies densely packed 3D biological samples by reconstructing objects in 3D space and identifying cell fates in zebrafish retina.

This study shows FGF2 increases growth fraction, promotes symmetric divisions, and shortens the cell cycle in Radial Glial progenitors, enabling their expansion in vitro.

The paper shows that Hh signaling in Drosophila ocellar retina uses a non-linear gradient as a temporal cue to generate a wave of differentiating photoreceptors at constant speed.

This study shows that drug treatment efficiency varies based on initial activation states in nonlinear pathways, revealing dose-response dependencies on network topology and initial conditions.