Fernando Casares

A sex-specific regulator expands the embryonic ocular field to generate a novel visual system

A Natural Programmable Metamaterial Controls 3D Curvature of Compound Eyes

This paper shows that the developing Drosophila eye functions as a natural metamaterial that programs 3D curvature through a supracellular triangular mesh pattern.

Expanding the fly eye gene regulatory network: from Drosophila to the hoverfly Episyrphus balteatus.

The paper compares the gene regulatory network of compound eye development between Drosophila and Episyrphus balteatus, finding conserved and species-specific regulatory interactions.

Gill regeneration in the mayfly Cloeon uncovers new molecular pathways in insect regeneration

This study investigates gill regeneration in mayflies, identifying conserved molecular pathways across insects.

Feedback control of organ size precision is mediated by BMP2-regulated apoptosis in the Drosophila eye

The paper investigates how feedback control via BMP2-regulated apoptosis ensures precise organ size in Drosophila eyes by balancing proliferation and differentiation.

Patterning on the move: the effects of Hh morphogen source movement on signaling dynamics

The paper studies how movement of the Hh morphogen source affects signaling dynamics in Drosophila organs, showing spatial and temporal differences in Ptc and CiA distribution.

Fly Cell Atlas: a single-cell transcriptomic atlas of the adult fruit fly

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals

The paper identifies a splicing program in neurons of Drosophila and mammals, showing how it evolves independently in different species to regulate ion channels and neuronal activity.

A new image segmentation algorithm with applications in confocal microscopy analysis

The paper introduces a new 3D image segmentation algorithm for confocal microscopy images and develops an application to implement it.

Dynamic Hh signaling can generate temporal information during tissue patterning

The paper shows that Hh signaling in Drosophila ocellar retina uses a non-linear gradient as a temporal cue to generate a wave of differentiating photoreceptors at constant speed.

Specific expression and function of the Six3 optix in serially homologous organs

The paper investigates the expression and function of the Six3 optix transcription factor in Drosophila wing and haltere development, revealing organ-specific roles in growth and sensory structure formation.

Increased avidity for Dpp/BMP2 maintains the proliferation of eye progenitors in Drosophila

The paper shows that Hth and Tsh maintain eye progenitor proliferation in Drosophila by increasing their avidity for locally produced Dpp/BMP2.