Hamid Bolouri

The paper applies a Variational Auto Encoder to single-cell RNA-seq data to identify dysregulated pathways in lupus, finding new insights without requiring expert user input.

The paper shows that RNA-seq processing pipelines produce inconsistent abundance estimates for over 12% of genes in at least 1% of samples, raising clinical concerns.

The paper uses network modeling to identify molecular mechanisms driving T cell exhaustion and validates predictions through experimental testing.