Karen M. Cerosaletti

Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression

This study integrates histopathological data from the human pancreas across T1D stages to identify novel histopathological correlates, particularly in the prodromal stage.

Companion to: A molecular basis for milk allergen immune recognition in eosinophilic esophagitis

This companion paper identifies a β-casein-specific TCR clonotype and its HLA restriction in a patient with EoE milk allergy, supporting findings from the parent study.

Unsupervised generative AI discovers pan-leukocyte dysregulated pathways in single-cell lupus data

The paper applies a Variational Auto Encoder to single-cell RNA-seq data to identify dysregulated pathways in lupus, finding new insights without requiring expert user input.

Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes

The paper identifies shifts in isoform usage in Tregs associated with Type 1 Diabetes by comparing gene expression between cases and controls.