Siobhan S. Pattwell

The paper analyzes bulk RNA-seq data from brain tumors and healthy samples to identify differential regulation of synaptic components and their impact on tumor progression and patient survival.

This study investigates how SARS-CoV-2 S1 protein induces systemic immune responses and long-term anxiety-like behaviors in mice.

This paper evaluates the combination of B7-H3 CAR T cells and ONC206 against DIPG models, showing enhanced anti-tumor efficacy in vitro and in vivo.

This paper uses topic modeling to identify developmental states in medulloblastoma subtypes across multiple datasets and technologies.

The paper designs TrkA agonists that activate neuronal differentiation and neurite outgrowth without triggering pain-related gene expression.

This study identifies CTPS1 as a vulnerability in MYC-driven medulloblastoma and shows that combining CTPS1 and CHK1 inhibition synergistically reduces tumor growth in vivo.

The paper combines five RNA-seq datasets to create a reference landscape of human brain tissues and tumors, enabling comparative gene expression analysis across normal and neoplastic samples.

The paper shows that RNA-seq processing pipelines produce inconsistent abundance estimates for over 12% of genes in at least 1% of samples, raising clinical concerns.