Feng Zhu

This paper introduces LucaOne, a foundation model trained on nucleic acid and protein sequences, demonstrating understanding of biological principles and performing well on related tasks.

TRAIT compiles nearly 8 million experimentally validated TCR-antigen pairs to provide a comprehensive resource for T-cell receptor interactions, aiding immunotherapy and vaccine design.

The paper identifies common host proteins involved in SARS-CoV-2 immune evasion and replication, suggesting them as targets for broad-spectrum antivirals.

OBMeta provides a web server for analyzing and validating gut microbial features and biomarkers related to obesity and metabolic diseases through integrated metagenomics analysis and cross-validation of public datasets.

AnnoPRO improves protein function annotation by using image-like representations and multimodal deep learning, showing better performance for rare protein families.

This paper introduces PRS-CSx, a method that improves polygenic prediction across ancestrally diverse populations by integrating GWAS summary statistics and sharing genetic effects.