Agnese Loda

The paper investigates the role of CTCF and cohesin in X-inactivation escapee domains and finds that these domains are self-sustaining chromatin compartments independent of CTCF and cohesin.

The paper shows that aged female CD8 memory T cells exhibit erosion of Xi transcriptional fidelity, linked to immune activation and clonal expansion, with similar findings in humans.

The paper identifies a female-specific neurodevelopmental disorder caused by biallelic CIZ1 loss-of-function variants, which disrupt X-chromosome inactivation maintenance.

This study shows Xist RNA modulates X-chromosome inactivation beyond early development, reversibly silencing escapee genes and altering topological domain structures in mouse embryos.

The paper examines how XIST regulatory networks evolve in primates, showing extensive diversification and the role of transposons and enhancers in different species.