Jasper Panten

Female specific erosion of allelic fidelity in aged CD8 memory T cells

The paper shows that aged female CD8 memory T cells exhibit erosion of Xi transcriptional fidelity, linked to immune activation and clonal expansion, with similar findings in humans.

Isoform-level resolution in single-cell CRISPR screens reveals hidden functional consequences of gene perturbation

This paper evaluates isoform-level resolution in single-cell CRISPR screens using long-read sequencing, finding that it captures splicing changes missed by gene-level analysis.

CRISPRi perturbation screens and eQTLs provide complementary and distinct insights into GWAS target genes

The paper compares CRISPRi perturbation screens and eQTLs in identifying target genes for GWAS-associated loci, finding they often identify distinct genes and complement each other.

SRSF2 transcriptional function maintains genome integrity during cell division

This study shows that SRSF2 mutations cause DNA damage and cell cycle arrest, highlighting its role in transcription regulation during cell division.

Four-Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage

The paper identifies an X-Y translocation in Four-Core Genotypes mice that increases Tlr7 expression and affects genetic interpretation.

Escape from X inactivation is directly modulated by levels of Xist non-coding RNA

This study shows Xist RNA modulates X-chromosome inactivation beyond early development, reversibly silencing escapee genes and altering topological domain structures in mouse embryos.

The function and decline of the female reproductive tract at single-cell resolution

This study maps the single-cell transcriptional and morphological changes in the mouse female reproductive tract across the estrus cycle, decidualization, and aging, revealing age-related fibrosis and inflammation.