Author

Samantha Leigh Sampson

South African Medical Research CouncilORCID 0000-0002-9596-8019Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alan Gilbert ChristoffelsiD· 1 shared Jomien MoutoniD· 1 shared Julian L Coetzee· 1 shared Melanie GrobbelaariD· 1 shared Mohd ShahbaaziD· 1 shared Nastassja L. KrieliD· 1 shared Ruben E.A. CloeteiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 9 mutual co-author links

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1 shared paperBioinformatics

Alan Gilbert ChristoffelsORCID

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2 papers

Recent·Most cited

Proteomic insights into a M. tuberculosis clinical isolate with an increased propensity to form viable but non-replicating subpopulations during acid stress

Nastassja L. Kriel, Julian L Coetzee, Jomien Mouton, Samantha Leigh Sampson

This study uses proteomics to analyze M. tuberculosis S169 under acid stress, identifying changes in protein expression associated with viable but non-replicating subpopulations.

Scientific Reports · Feb 13, 2026Peer-reviewedMicrobiology

Repurposing Novobiocin for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyltransferase (Rv2421c)

Ruben E.A. Cloete, Mohd Shahbaaz, Melanie Grobbelaar, Samantha Leigh Sampson, Alan Gilbert Christoffels

The paper identifies Novobiocin as a potential repurposed drug against Mycobacterium tuberculosis by targeting Rv2421c, through computational screening and in vitro validation.

bioRxiv · Jul 30, 2020 · PreprintBioinformatics