Influenza A virus transcription generates capped cRNAs that activate RIG-I
Elizaveta Elshina, Emmanuelle M. Pitré, Marisa Mendes, Brandon Schweibenz, Rebecca L.Y. Fan, Hollie French, Ji Woo Park, Wei Wang, Leo L. M. Poon, Joseph Marcotrigiano, Alistair B. Russell, Aartjan J.W. te Velthuis
This study identifies a novel IAV RNA species, capped complementary RNAs (ccRNAs), which hybridize with viral RNA to activate RIG-I, revealing an alternative mechanism for innate immune activation during IAV infection.
bioRxiv · Nov 12, 2024 · PreprintMicrobiology