Tomáš Kouba

The paper identifies HelD as a transcription factor that enhances gene expression in rapidly growing mycobacteria and reduces it in stationary phase, with implications for rifampicin resistance.

This study uses cryo-EM to observe how influenza polymerase backtracks after incorporating T1106-MP nucleotides, revealing structural changes that lead to chain termination.

This study identifies HelD as a nucleic acids-clearing factor for RNA polymerase in Mycobacterium smegmatis, revealing its role in recycling RNA polymerase by preventing non-specific DNA interactions and dissociating elongation complexes.