Author

A. Pflug

European Molecular Biology LaboratoryORCID 0000-0002-4680-1298Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

S. CusackiD· 2 shared Anna DubánkováiD· 1 shared C. Isel· 1 shared Chris MeieriD· 1 shared Elisa DonatiiD· 1 shared Johanna HuchtingiD· 1 shared M. Lukarska· 1 shared Marco De VivoiD· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

S. CusackORCID

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2 papers

Recent·Most cited

Backtracking of influenza polymerase upon consecutive incorporation of nucleoside analogue T1106 directly observed by high resolution cryo-electron microscopy

Tomáš Kouba, Anna Dubánková, Petra Drncová, Elisa Donati, Pietro Vidossich, Valentina Speranzini, A. Pflug, Johanna Huchting, Chris Meier, Marco De Vivo, S. Cusack

This study uses cryo-EM to observe how influenza polymerase backtracks after incorporating T1106-MP nucleotides, revealing structural changes that lead to chain termination.

bioRxiv · Jun 10, 2022 · PreprintMolecular Biology

Type B and Type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD

T. Krischuns, C. Isel, P. Drncova, M. Lukarska, A. Pflug, S. Paisant, V. Navratil, S. Cusack, N. Naffakh

This study compares the binding interfaces of influenza B and A polymerases to the host RNA polymerase II CTD, revealing distinct evolutionary adaptations for host range.

bioRxiv · Feb 4, 2022 · PreprintMicrobiology