Jeremy R. Lohman

This study humanizes the rpb9 gene in fission yeast to examine the functional and structural conservation of POLR2I, revealing both conserved and divergent roles in growth, aging, stress responses, and chemoresistance.

The paper reports that E. coli heteromeric acetyl-CoA carboxylase forms polymorphic helical tubular filaments, revealing protein-protein interactions that support catalysis and mask transcriptional regulation.