Xiaoting Hua

TattleTail identifies pyocin-encoding gene clusters in Pseudomonas aeruginosa genomes, distinguishing them from prophages by lacking canonical phage features.

This study uses AlphaFold 3 to identify and characterize phage proteins that inhibit bacterial transcription, revealing novel mechanisms of action.

This study uses single-cell RNA-seq to reveal concentration-dependent survival trajectories of Acinetobacter baumannii under antibiotic treatment, uncovering hidden heterogeneity and resistance mechanisms.

This study identifies a wspA mutation in Pseudomonas aeruginosa that increases c-di-GMP synthesis, leading to rugose small colony variant formation and enhanced biofilm-mediated antibiotic resistance.

This study identifies a WYL family protein in Moraxellaceae that regulates both DNA damage response and anti-phage defense networks, enhancing understanding of bacterial immunity and antibiotic resistance.

The paper analyzes prophage distribution in A. baumannii genomes, finding two common families, variable prophage numbers, and AMR gene carriage in prophages.