Jinxin Zhao

Impairment of bacteriophage activity in blood: a case study revealing constraints in phage isolation and translation

This study develops a new phage isolation method and evaluates phage efficacy in different biological matrices, finding that phage activity varies significantly and sustained activity depends on maintaining favorable phage-to-bacteria ratios.

Ionic regulation of Gram-positive phage adsorption governs host range and improves phage isolation efficiency

The paper shows that adjusting ionic conditions improves phage isolation from Gram-positive bacteria and expands their host range.

Characterisation of SpoT-disruption induced metabolic shift in bacteria

This study investigates the metabolic changes in a spoT-disrupted Acinetobacter baumannii mutant under polymyxin treatment, revealing altered metabolite profiles linked to increased antibiotic susceptibility.

Single-cell transcriptomic dynamics exposes hidden survival trajectory under antibiotic treatment

This study uses single-cell RNA-seq to reveal concentration-dependent survival trajectories of Acinetobacter baumannii under antibiotic treatment, uncovering hidden heterogeneity and resistance mechanisms.