Jiao Zhang

This study identifies AHCY as a key driver of epigenetic and metabolic reprogramming in ZFTA-RELA ependymomas, revealing its role in promoting tumor growth through pyrimidine synthesis and asparagine dependency.

This study identifies metabolic partnerships between medulloblastoma and macrophages that drive leptomeningeal metastases and suggests targeting the CXCL12-SCARB1-cholesterol axis as a therapeutic strategy.

The paper identifies ependymomas as originating from the pre-neural crest/roof plate lineage using single-cell transcriptomics and lineage tracing.

This study identifies a CNV involving three enhancers that drive bilateral constricted ear malformations by coordinating HMX1 expression through distinct regulatory mechanisms.

DeepVelo estimates cell-specific transcriptional kinetics in scRNA-seq data using GCNs, enabling analysis of complex differentiation processes with time-varying rates.